Directed at you: I would try to avoid such software, and look for alternatives. (I expect this to be futile?).
x86 is available across the world as well. Others already pointed out comparable form factors.
Also, computerhardware reliability is pretty good these days. Maybe you could set up a scheme to reuse your tech stack?
On the extreme end, server hardware can run for years with 0 hardware-related downtime (and offers nice things like redundant power supplies, 19" rack cases [but much deeper than audio stuff?]). And brutal performance: Even my 450 Euro used&modified (new nvme disk, faster CPUs), 5y old, 1u(!) Intel dual socket system can mop the floor with most desktops below a Ryzen 3900 (at least on my compile workloads, and on anything that swaps on less than 128GB RAM in general).
They don't run macOS, so won't run your software though.
So not an intel nuc then, which is what I was specifically referring to.