I started an opiate taper at 40mg loperamide a day and while I didn't feel euphoria it definitely had a strange, almost dissociative high. On other forums people report therapeutic effects up in the 100mg range, but ymmv
Starting at 40mg - thats sounds really high. I wonder whats the effect on the gut. Doesnt the food get backed up a lot which leads really really bad constipation or is that not as pronounced.
It was a long time ago; I think I mixed in miralax. I don't remember any gut issues.