I get constant audio issues where dialog from one NPC is either not coming through or sounds like it's from 100ft away. I've also had problems getting the next part of a mission to trigger when you're supposed to wait a day for the NPC to call you back (one particular one, I waited an in-game week with 2 game reboots to trigger it). I randomly get stuck in the zoomed view. When I'm being passed a shard by an NPC, it's randomly replaced with a gun. Multiple areas at ground level throughout the map with gaps in collision resulting in you falling through the world. I've been stuck in rooms multiple times where the input prompt to open a door simply never triggers and I'm unable to open the door, requiring me to reload from checkpoint. Texts from NPCs come in the wrong order. Forced NPC calls in the middle of dialog during a separate mission. Sometimes unable to choose dialogue options when driving, requiring me to stop in the middle of the road to get out to give the response I want. Sometimes unable to do absolutely any blunt melee damage, which has resulted in a stuck loop requiring a reload (like the boxing robot near the beginning of the game)
The list goes on and on. With that said, I'm playing on PC with pretty decent performance all things considered, I've tolerated them because I'm still enjoying the game, and I wouldn't classify any of the bugs as necessarily "game breaking", but they're significantly detracting from the enjoyable game and narrative underneath.
It's almost as if not a single gameplay aspect has any sense of polish whatsoever and that sucks.