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We need accelerated testing. In the case of a pandemic, we need to make better use of volunteers.

How would you attract volunteers for these less-safe clinical trials? Pay them money?

You'd ask. I recall seeing multiple human interest stories about people who were eager to volunteer for challenge trials. I believe challenge trials are how the original vaccines were tested in the earlier 20th century prior to contemporary developments in medical ethics.

And you'll get volunteers. It's a rational decision for effective altruism. Say you face a 1% chance of death but a 50% chance of substantially contributing to saving a million lives. If that's technically possible, highly informed people should have the opportunity to make that choice.

I believe some of the earliest challenge testers were the developers of the drug themselves.

1daysooner.org lists almost 40,000

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