Changes from one release to the next probably won't matter very much to most individual users, unless something specific you're using is getting support added, but you'll usually find at least one or two major features between LTS releases, including stuff that impacts ecosystems beyond just GNU systems.

Wireguard and exFAT are a couple of notable ones that have been mainlined since 5.4, with the latter impacting basically anything that uses SD cards (as it's a required part of the SDXC spec)