I'd learn vanilla first. Do some project euler or similar coding challenges, get familiar with different syntaxes & structures. All this depending on how familiar you are with programming, I guess.

And then pick up a framework, keeping in mind that these frameworks are pretty complex; probably inscrutable to people without some coding experience, even if it were in another language.

Not OP but I've been working with JS for years.

You'll need to learn Vanilla JS before diving into a library like React, Anular, Vue, etc. At the end of the day, you're still writing JavaScript.

You could get a job with just JS knowledge, but you'll have a lot more luck with a popular framework/library stack.