Water!
This might sound a little weird, but I use a nose spray (any atomizer will do) filled with water and spray on my closed eyes when I feel like it.
I started doing this this year and it helped me tremendously. No more eye strain!
Before that I tried EVERYTHING!
* Dark Mode
* Night mode (Flux etc.)
* Changing Brightness
* Changing ambient light
* a few different eyedrops
* Looking away more often
* Sitting farther away from my monitor
* Different monitor positions
* Different monitors
* Sitting less in front of a monitor
* Bigger Text
Nothing helped me. I asked my doctor and he couldn't help me at all. Sprinkling some water onto my eyes? It just works.
(I guess my eyes are just overheating or something? But honestly I have no idea.)