125% DPI or 125% "zoom" depending on the OS/application help with eye strain massively, and it surprises me how few colleagues are willing to try it (e.g. "I can see perfectly, why would I increase text size?!").
Between that and lowering a monitor's brightness to below 50% (often around 35% depending on brand), are my biggest tips. Windows now has a blue light filter built right in (Settings -> System -> Display -> Night Light).