Other than the fact that this method gives a full message, the message contains actual phrases which are very very relevant. For example "THAT WASNT ME ON THE TV SHOW" refers to someone who called a TV show 2 weeks before this letter was sent [0] pretending to by The Zodiac. Similarly, in that talk show, they discuss fear of "THE GAS CHAMBER", another phrase that appears.
These two alone make it astronomically improbable that this is random. There are a couple other similar phrases, such as his common misspelling of Paradice, and him frequently referring to people he killed as his "SLAVES" in the afterlife.
[0] https://www.youtube.com/watch?v=4yrtcRBTg-I
(The talk show happened on October 22, 1969. The letter was sent on November 8, 1969.)