I have tried it a long time ago (4, maybe 5 years ago?). Many, many things broke and I didn't have time to fix them all.

I already use the strictest Tracking Protection stuff in Firefox, for example, and I do hit sites that don't work correctly.

Maybe it's worth revisiting but something tells me that the web uses more JavaScript, not less, since I last tried this experiment.

And regarding the patronizing aspect, let's say your bank's website uses JavaScript, what do you do?

Edit, actually, sorry, I re-read your comment and you answered my question:

> I don't give a damn about other sites (and I don't browse intranet sites on my home machine -- if I'm in an office I use their office machine). If they don't work I don't use them except in rare cases when I really need to in which case they get run in a VM.

Q.e.d.

I'll just rephrase things to something less offensive: you're not "hurting" yourself, you're limiting yourself, sometimes with drawbacks not everyone is able/willing to endure.