Of course if your intent is to be inactive then all bets are off. Even if you're not I don't think those little nudges are that effective.
Personally I've been working lying down for 20 years, almost all day, almost every day. I only have back problems when I use beds that are not very firm.
I'm over 6 feet tall and weigh about 120 kg and I'm in my early 50's. I run 10kms (without stopping except for quick drinks) regularly, in 1:20. I can do bench press, shoulder press, lateral pull down, seated row and seated dip machines with the weight set to my bodyweight (about 4 sets of 8 reps each machine, ramping the weight).
I actually don't do a lot of exercise on the scale of things, and I can regain the above abilities within a month or so if I become totally inactive for a long period. I'm actually a fairly large person which helps with the weights but makes the running pretty rigorous.
Like most things, if you work your body regularly you will be fine. How you don't use your body when you're not exercising doesn't affect that.