ctrl-r <register> pastes that register into your command.
So I often need to find "where is this method defined" across a large project.
yw (yank word to get method into the " register)
:Ack <ctrl-r>" (ack plugin, paste that default " register)
<enter> yay! I found it.
Alternately: /foo (attempt to find foo in this file. Whoops, not there, where is it!).
:Ack <ctrl-r>/ (last search is in the / register).
There it is!