Real estate is local, my house in Alabama has returned sub 1% annualized in appreciation, my house in Washington as returned about 6% annualized. Where supply is constrained, prices are going up, where there is excess, prices aren't even keeping up with inflation. Seems like a perfectly rational market to me.
Financial assets is far too broad a category, but "markets can remain irrational far longer than you can remain solvent" isn't some new statement. I'd argue that this is more a consequence of a confluence of factors including the end of general scarcity of capital, low interest rates, and low taxes.
Medical and Education costs are structural issues within the US, see most of Europe for a counter example.
As far as outsourcing, well that has lifted over 1 billion people out of poverty...so yea, I got nothing for you if you think American's being able to buy more goods for fewer dollars while simultaneously making the world a better place is something to be concerned about.
And our economy is far more stable today then any time in the history of the US. Or are we going to pretend that multiple depressions didn't happen in the late 19th and early 20th centuries? The only reason that the 2008 recession was as bad as it was, was because of a lack of political will to spend money.