Well, I did spend hours playing on flying simulators with the default inverted axis (yoke down to climb up, yoke up to climb down) and I do not invert the axis when playing other types of games. Anecdotal but this is true for my friends that play/played the same type of games.

I don't think this is true. At least not in my case.

Though I am left handed, so maybe the fact that I've spend most of my life adapting to a right handed world has something to do with it.