Another issue with evented frameworks in python is that you have to ensure nothing is blocking anywhere in your code, which becomes harder the more complex your application becomes. People will often mention IO, database, etc... forgetting that it is also an issue if your request handler takes CPU for N ms (e.g. encoding a relatively large payload in json, etc...). everything needs to be written with async in mind.

Languages/frameworks where async IO is an implementation detail (like some web frameworks in haskell) don't have this issue.