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I'm a DevOps engineer living in Europe with 10+ years IT experience. No formal education.

What's the best path to work and settle in the US with my wife?

What's a good but reasonable salary that I could achieve?

Salary will depend heavily on where you want to live. As someone else commented, SF salaries are insane.

If you don't live in SF, your salary will not be that insane. Seattle/New York will be close.

Expect $175,000 to $300,000 compensation.