Cataclysm DDA is probably my favourite, but I don't like playing more than a single character at a time, and when I get too far into the endgame, I get bored with it, I usually just kill my character in some ludicrous/stupid way.
That's usually when I play Dungeon Crawl Stone Soup. I think the recent versions are all garbage (I guess there's some pitfalls to democratized game-development), I play strictly version 23.0.
Between these two games, all my of roguelike itches are scratched. I'd say CDDA is sort of like single-player only Dwarf Fortress, and DCSS is Rogue/Angband distilled.
FTL is an INCREDIBLE game, but I've given it up cause it's proprietary software.
I also played some Tales of Maj'Eyal, but imo it's too combat focused for what RP elements are in it.
I've beaten all of these games, and DCSS around 20 times.
I recommend them all thoroughly.
Honorable Mentions: 1) Shattered PD for mobile 2) Slay the Spire