This is precisely where Tailwind breaks down IMO. It's fast for landing pages and smaller sites--but when implementing a real design system across a complex web app, Tailwind is a nightmare. We've had to add so much custom stuff to the config file it's basically the same mess our CSS was before.
I've been-there-done-that with the whole CSS framework world (have used Bootstrap, Tachyons, Bulma, Tailwind in many projects) and have completely reverted back to custom stylesheets with a few select utility classes that make sense.
Padding, margins, widths, heights do not make sense as utility classes IMO.
Type scales, type modifiers (like font-weight), and commonly used things like margin-x-auto and 100% width do.
I wish there was a CSS framework that only contained a minimal set of common utilities (like the ones mentioned above) and required no complex build process BS or NPM.
I just want a simple boilerplate, nothing else.