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If you're using IronPython then you're probably just trying to embed a familiar scripting language into something, not trying to adopt the Python ecosystem.

Besides, while you lose out on Python's native ecosystem you gain access to all of .net's.

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I'm not disputing that IronPython can be useful (although one also has to consider https://github.com/pythonnet/pythonnet, which wraps CPython into an IronPython-like projection). But if it can't share the library ecosystem, it might as well be a different language for all practical purposes. And it turned out that there aren't enough people who were interested in a Python/.NET combo for its own sake, so it remained niche. Any new implementation of Python on top of .NET VM would likely get similar reception for all the same reasons.

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