Anyone remember Boo? [1] It was a Python language that ran on the CLR/DLR VM of .NET. It was used early on in Unity when it had C#, Javascript and Boo. It was the language that coroutines was first implemented in that used Python like generators behind it.
There was also IronPython added when the DLR came out and is still updated to this day, latest works in .NET Core. [2]
It would be fun for Python to have more focus with Microsoft tools and some things on Azure or even another Boo/IronPython like CLR/DLR virtual machine language or more focus on IronPython itself as well as more of CPython. Having Guido at Microsoft is awesome.
[1] https://en.wikipedia.org/wiki/Boo_(programming_language)