Not if you're holding onto it using a magnetic field, or any other method that doesn't involve direct contact.
By contrast, if you were holding a lump of antimatter contained by an electromagnetic field, a power failure would result is the antimatter escaping confinement and annihilating with your body, releasing an unimaginably large amount of energy nearly instantly. This is what you might call a "fail-deadly" system, because a failure results in a decidedly unsafe state.