At that point, it seems to me that there isn't much left to distinguish the virtual machine from the physical. Behavioral properties of the CPU? Anyway, that's what I meant when I said it seems like after a certain point, it becomes impossible to tell the difference.
EDIT: based on the link above, it looks like current state-of-the-art doesn't go far beyond making sure names and common virtualbox performance shortcuts aren't present. https://github.com/hfiref0x/VBoxHardenedLoader/blob/master/B...
What else is there that could possibly indicate virtualization? Available instruction sets? Strange limitations of the given CPU? (e.g., the cpu presents itself as some Intel chip that's known to have 4 cores, but there's only 2 available)
[0] https://secret.club/2020/04/13/how-anti-cheats-detect-system...