I have a basic ritual of how I set it up, and it helps get into the mindset of working.
First I prepare the space for my computer by removing anything unrelated and adding keyboard, charger, mouse, LED candle, and tea/coffee cup.
Then, I ceremoniously place the computer in the middle, line up and connect the components, and boot it.
I say a prayer of intention of what I hope to accomplish and move my praying hands down towards the G and H keys to ensure that my keyboard is centered.
Then, I'm ready to work.
If anything distracts me, I go through the following mental process, which becomes easier every time as it's habituated:
1) I thank the distraction for reminding me to focus on what is important.
2) I take a slow deep breath in and then let it out slowly.
3) I return my focus to my work and my intent.
4) I rejoice that I was able to succeed once again in remaining focused and mindful on my task.
So yes, I do have a dedicated space for work: It is inside my mind's eye and my awareness, as well as the desk and chair I am sitting at/on, and where I am currently focused on the screen. :)