The second took a large dose about a decade ago and after being a very conservative straight guy. Mormon. Straight A's. Didn't take drugs or drink. He immediately dropped out of school, moved in with a prostitute and decided he wanted a sex change. That was 10 years ago. Last year he had sex reassignment surgery in Thailand.
In both cases I suspect the drug opened pathways that were suppressed. I see LSD as a truly mind altering drug. In rare cases it alters minds for the better. In many cases it exposes latent problems that can be debilitating and life-destroying.