As someone with major depression, it helps temporarily but doesn’t last.
I'd have assumed it meant a tolerance would kick in after a few rounds.
1 reset day out of every 100 does sound achievable/possible even with clinical administration, but needing it every 3 days wouldn't be.
Consider normal SSRIs where you feel like crap for a month, try N more (which could mean many more months) until you find one that suits you, then have side-effects, then try to get off them so that's another couple of months of misery.
That's countless doses, money, time spent in misery vs one day of mushrooms every 3 months.
Normal psych meds are to be avoided at all costs and only be used if absolutely necessary, after you have tried everything else; atleast in my opinion.
Psilocybin is an intense acute experience. People can have negative effects. I hope we do studies to find how to use it most safely, or isolate the beneficial aspect without the intoxicating effects.
Though some take greater dosages, many people are finding relief from sub-perceptual doses: indicating that the typical hallucinations and disorientation associated with recreational psilocybe use is likely not necessary for achieving anti-depressive effect.
I've also read of some interesting work being done creating "anti-abuse" formulations, where the active ingredients are compounded with Niacin or other drugs that cause unpleasant physical side effects at high doses to discourage overdose/abuse/recreational use. "Stamet's stack" seems to be the most common of these.
Definitely needs much more research into these compounds, but seems a very promising frontier for antidepressant pharmacology.
Of course they can’t just let us use the natural substance that has existed for most, of not all, of human history.
Psilocybin works great, and almost everyone I know with depression can attest to that- but without changing the circumstances that cause the depression it will likely always return.
Anecdotal example: My sister is in disability care and is routinely abused by patients with severe disabilities (to no fault of their own) and she will slip into a severe depression that usually lasts a long period of time. Tripping helps her substantially deal with this, but psilocybin is for treating the effect and not for fixing the cause... If you kick a dead horse it (probably) won't wake up.
Repeated again roughly yearly. After 4 difficult and unpleasant trips I'm fine. Never reached the sense of utter well-being I have for the few months after a trip but I'm fine.
I will say that drinking any alcohol basically negates the positive effects for me for a while. As in, I'll have a cocktail and then won't feel "right" again for a month or so.
I've had a very bad experience w/anesthesia so am always nervous while dealing with anything of that nature. Wonder if that predisposes me to a bad trip.
Not sure that would be worth it for just 2 weeks of relief.
Also not sure I'd be able to find any such doctor near me. Probably health care providers are much more open minded out West than it is here.
As to monoideism's question: I'm not a doctor, but ketamine is more benign than many other anesthetics especially at the lower doses used in treating depression. Do your homework, but don't rule it out based upon prior experiences with other anesthetics.
It’s a shame too. I had the best health care option from one of the largest public tech companies and I had to pay $450 out of pocket, twice a week for four weeks, and then moving down to every other week. This is on top of $6k they took out of my salary over the year.
It is extremely frustrating the amount of basic mental health care needs, which I believe depression is, that are simply out of reach for most of Americans.
Maybe vaccines or antibiotics (depending on how you define 'permanent'), but I don't think any psychopharmaceuticals fit this description.