While I've personally never tried LSD, my favorite is, e, which offers a similar, but different, opening of the mind. Since I've never tried LSD, I can only say that e opens one in an emotional way, one that allows you to empathize and understand the universe in a way that you otherwise wouldn't. It also invokes an odd existential dialog within oneself about how the world works and why we think the way we do.
I suppose I quote you because as a musician and software engineer, it is often the case that I ask myself why it is that certain things are the way they are. For example, anyone that's studies AI realizes that one of the harder concepts is that of _understanding_.
How do we make a machine understand when we ourselves don't understand the _why_ around us?
Drugs like e and LSD present an insight to us that allows us to realize that the answer is a lot more distant than just what we perceive.