European colonials in the 16th through 20th century were most definitely not similar to Iron Age versus Stone Age contact. The bulk of US actions against the Native Americans in the West occurred around ~1870[1]. "Might makes right" is poor justification for those who ostensibly professed ideals from the teachings of Jesus Christ, the Renaissance, the Enlightenment, and the Age of Reason. I think we are right to judge European colonials harshly by their own moral standards.
[1] See the book, "Bury My Heart at Wounded Knee"