20% isn't nothing... but is it really worth switching to a non-standard, closed-source version of the interpreter?
In some cases a rewrite may save more money than moving to a 20% faster python.
Rewriting in a more efficient language might seem even cheaper, but you have to factor in risk and opportunity cost. At some point it does become smarter to rewrite, but your app needs to be pretty simple or your server bill pretty huge before it’s actually the best option.