It's been awhile since I've messed with a GUI in python, so I did quick image search to see just how ugly it is. And it actually looks very serviceable. A bit utilitarian, perhaps, but not too bad. I was expecting much worse, like the old Tk dialogs. And judging by the variety of examples I found, it can be themed to some degree. My only problem - and what has driven me to use web apps in the past - is the difficulties in bundling and distributing python apps.