Use of adenovirus type-5 vectored vaccines: a cautionary tale

Additional commentary and background can be found in Science;

https://www.sciencemag.org/news/2020/10/could-certain-covid-...

The concerns raised in this article do not speak to the efficacy of candidate vaccines using Ad5 vectors. Rather, they discuss the potential impact Antibody-dependent enhancement might have on at risk groups, and, as a consequence, for the design of clinical trials using those vectors.