Using reserved instances would push the EC2 figure down 30-40% (and like the dedicated option, provide further cost savings in years 2 and 3)
You can't assume that the marginal increased technical management cost is zero. If that's true, you're employing people that aren't doing anything productive with their time. A dedicated cluster of this size would likely consume 50-100% of one employee's time, which adds at least another $50k to that side of the ledger.