If you only control the client then you could make your http/fetch requests as big as possible, i.e. do the Nagle algorithm yourself but at a higher level to avoid the delays, but I don't think there's not much else you can do.

Then again, if you control the server you could just run HTTP/3 to be on QUIC and then you're not on TCP any more, you would also save alot of connection handshake latency and benefit from advances in bufferbloat-sensitive congestion control algorithms much quicker.

To be fair, I would be more concerned about bufferbloat delays on small shared networks than delays due to Nagle's algorithm. Bufferbloat delays can be up to tens of seconds, and you can trigger them disturbingly easily, just have someone else in the office upload a large attachment to an email in Gmail's web client to saturate the router's send buffer, while you watch your ping times.