I was trying to say that the comment isn't transphobic at all, and if people think stuff like this is the reason why trans people kill themselves then they're probably blind to the actual transphobia that happens in the world.

Also, I strongly believe that we shouldn't be restricting language out of fear of being offensive, because then people become too afraid to talk about important issues.

First, stimulants have a release schedule and are generally not a 24-hour thing. You wouldn't be able to sleep if they were. The effect depends on plasma concentration and varies during that interval. You might feel extremely focused at first, then energized but not especially focused, then a total drop in energy and focus when you hit the "down" part of the curve. Everyone's response is slightly different, however. I definitely think differently in the morning (after taking the pill) vs. at night. Sometimes I have an insight while relaxing in the evening that I write down and becomes my focus in the morning, when I'm better able to work.

Second, it's not easy to put into words but the focusing effect is different from the cross-topic creativity you're talking about. Amphetamine is like a really strong, long-lasting coffee without the negative side effects that would come from drinking pots of coffee at a time. Plenty of creative people drink regular portions of coffee. It lets you focus on your work without unwanted distractions. But by increasing working memory, stimulants actually increase the incidence of cross-domain insight, in my experience, because you're able to keep more concepts in mind while you're working.