Nuitka compiles Python to C using the Python C-library (something Cython is also capable of), with a focus on portability. Nuitkas main goal is not speed (compared to Cython), but the ability to output an executable binary (plus a bunch of dynamic libraries) needed to run your program in a portable, "interpreter independent" way. From the "What is Nuitka" page[0]:
> It translates the Python into a C program that then is linked against libpython to execute in the same way as CPython does, in a very compatible way.
Once they managed full compatibility (I think it was in 0.4?) then they started to focus on optimizing and translating even more things to C (again, keeping compatibility at 100% -- so you shouldn't event run into Nuitka-specific issues).
I've used it to deploy a few custom triage programs in the field for DFIR operations where we'd want to run a few specific things from portable drives without installing anything in the triaged computer.