Going back to 2006, Xilinx was making FPGAs that would sit in an Opteron socket and speak HyperTransport to the other CPU(s).
I never heard much more about that, but I can imagine it might've been popular with certain specialized workloads, in an era before GPU compute took off, or perhaps workloads that don't fit GPUs well.
I wonder if those specialized applications might be a small but important market.