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Comment by jychang | Hacker News Reader

Depends on the dose and drug. 5x the dose of adderall is probably pretty fun.

Adderall/Vyvanse/Amphetamines don't interact well at all with vitamin C, of which grapefruits are full of. So sadly enough, you don't get any 5x intake boost with the enjoyable meds. Would have been way too much fun ;)

Isn't the vit C thing just because of acidity? Combining with a teaspoon of NaHCO3 would cancel that out, no?

But apparently the effect lasts up to 12 hours, vitamin c should be gone from the stomach by then. Grapefruit has been anecdotally recommended for MDMA (an amphetamine).

The reason it's recommended for MDMA is because it inhibits the CYP3A4 enzyme which metabolizes MDMA (3,4-Methylenedioxymethamphetamine) to MDA (3,4-Methylenedioxyamphetamine). MDA is more neurotoxic than MDMA which is why it's advised to reduce the amount your body intakes.

The majority of adderall breaks down through the urea cycle due to urine acidity. Enzymes don’t play as significant a role as they do for other drugs. That’s why baking soda is the best potentiator for amphetamines, as it neutralizes urine acidity.

For anyone considering actually doing this, beware that it needn't take much baking soda to be harmful. People have died from overdosing.

Maybe someone with journal access can dig out dosage ranges from any of these many sources: https://scholar.google.com/scholar?q=related:4ssWhTcQeYEJ:sc...

As someone prescribed Adderall, to my knowledge, grapefruit juice (and citrus in general) will inhibit the absorption so if anything, it would just lower the effectiveness of a typical dose.

If by “fun” you mean think-your-heart-is-about-to-literally-explode and lie down in fear for 8 hours.

(Source: have accidentally double dosed my amphetamine Rx. A 5x dose would probably be lethal.)

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