I optimize my keyboard to programming. I already have a second layer for programming specific functions. I could add a third, but it's more mental load. It's not worth it.
Things that I'd put onto this:
* Mute/Unmute for Zoom * Screenshot key * Bind to a few key apps so I can switch between them quickly * Media and volume keys (so I can use a smaller keyboard, but have these within react) * A few emojis just for fun. * I'd likely have a toggle so it could serve as a num pad