At the highest level, a company is a group of people who get together to 1) set an impactful goal, and then 2) work very hard to achieve it. The first part — the setting of the goal — is the political act. Disagreements at this level are good, and broadly healthy.
But the second part — the achieving of the goal — is purely a practical act. Here, your guiding principle is to take those actions, and only those actions, which you believe will give you the highest chance of achieving your goal.
Politicizing a company contradicts this principle: to the extent that you make the act of achievement more political, you are also making it less practical. To the extent that you allocate more budget, focus, and optimization power to X, you are also taking it away from Y.
If you make the act of achievement less practical, someone else may beat you to your goal. Your company will be less impactful than it could have been, and may even die as a result.
What Brian is saying here is: we set our goal in 2012 when we started Coinbase. We are now engaged in the practical act of achieving it. If you have a goal that's different from the one we set, no problem. Here is some money: you may use it, if you choose, to find an organization whose goals you support.