Neuroquant imaging filters for MRI are supposed to detect changes like this, but are quite expensive and not readily available. The pediatricians shrugged their shoulders. Functional medicine doctors would be more willing to pursue this approach (they like data). The trick is finding the root cause of the swelling, which is usually an immune response to a protein it does not like and wants to isolate. I am unaware of other locations in my son's body that become inflamed by Annatto, his stutter was/is the first notable symptom.

Is it the Annatto itself that collected in my son's brain/frontal lobe and triggered inflammation? A brain scan at that time would probably help shed light.

Was something else there that Annatto reacted with/killed and my son's system inflamed due to the residual proteins (it's used as an anti-parasitic in native cultures - and yes, herbs can cause a die off as most lyme+ patients have demonstrated repeatedly - and I will get forehead pressure from a die-off, my son might be similar in that regard)?

In short, there's not enough data or an easy way to gather it.