Older people have become younger
jyu.fi
jyu.fi
Those actresses were all ~63 when it started (one was 53).
But by today's standards, they look like they were all 70-80.
It's remarkable what our current "norms" of fitness and nutrition have done. Or conversely, the toll (and associated clearly visible accelerated aging) that normalized heavy drinking and smoking took on older generations.
https://greekcitytimes.com/2020/05/15/betty-white-to-star-in...
Also, not that I think following is good thing, but check how geriatric us supreme court is or politicians are.
Or even just sunblock?
My city website has so many popups / popover you have to accept EVERY single time you visit it is not usable on mobile. Accept / decline I don't care on cookies. And many websites just bump you off the website if you don't accept.
I'm serious - when you have ISPs selling your browsing history, addins and trackers and website profile tools live capturing your every mouse movement, are cookies the great evil of the internet that must drive a billion (?) click on "accept" every day?
My own solution - allow for an "I accept cookies" header - you set it ONCE on your browser and people owe you $100 if they show you a cookie popup. Now THAT would be a law I could get behind!
Lawmakers are living in some imaginary universe where consumers read the terms and conditions of every website they visit. Their privacy laws are seriously out of touch. Or maybe they're designed purposefully to be that way.
So most sites could choose to give up analytics (altough tbh the most important metrics would still be fine like daily page hit count, etc.) but it's easier to add the banner and blame GDPR.
But perhaps, once a company is a certain size their legal department just screams all day about needing a cookie banner? Also very possible.
https://webmasters.stackexchange.com/questions/114973/are-se...
If you include non-essential cookies (like, for example, tracking cookies set by two or three hundred advertisers), you must ask the user for their consent. The site must have "decline all" as the default option, and should continue to provide basic functionality when the user declines.
All the banners that don't have the opt-out option or making it difficult to opt-out willfully break the law.
And yes, GDPR is a good law.
You run a shopping cart. As part of your fraud detection you put a fraud cookie beacon on every page. Is the fraud beacon essential?
As part of your product development / ab testing etc you track users on your website. Is this essential?
For affiliate link fraud control third parties want to have a cookie on your site that leads through to their clickthrough link. Essential?
Reality - you need to stick up a cookie banner to operate a website or get into long complicated legal arguments and face big liability. And that's what folks do, including practically every government agency.
Also, most sites would rather you accept cookies than not do so, that's why they're giving them to you. But I don't think most websites rely on surveillance in any meaningful way, the landscape is just guided by the ones that do.
As a European profoundly attached to privacy and whatnot I think that there should be a special place in hell for the useless consultants and politicians who came up with this idiotic cookie law.
In other words, California probably isn't a wealthy state because it is less obese than most other states. It probably less obese than other states because it is wealthy.
There are both rich and poor countries near the top of the list.
Of course, it is more than one variable. Reality tends to be multidimensional.
Some of my classmates look pretty rough. Others remain vital.
I'm sure genetic and zip code lottery are huge factors. But the kids who never stopped partying are much worse for the wear.
Some people live hard.
Given that the age group they are looking are already well in their 70s, they might not be heavy internet users. It's hard to tell from these studies that internet had any effect to their health.
In fact, I think we have to wait another ~30 years to see when first internet natives become 70 year olds if it has any effect.
Caloric restriction, and fasting, are already well known and are not revelations to be found in his book.
Beyond those suggestions, nothing he talks about can the average person take do.
But regardless, my interest is as much in the general progress that's being made and the speed at which it's accelerating. It left me feeling extremely optimistic about what the next 20-30 years is going to hold in terms of developments in anti-aging science. Unless we blow ourselves up in the near future.
Balasubramanian, Priya, Porsha R. Howell, and Rozalyn M. Anderson. “Aging and Caloric Restriction Research: A Biological Perspective With Translational Potential.” EBioMedicine 21 (June 19, 2017): 37–44. https://doi.org/10.1016/j.ebiom.2017.06.015.
For primates, this is a good review:
Mattison, Julie A., Ricki J. Colman, T. Mark Beasley, David B. Allison, Joseph W. Kemnitz, George S. Roth, Donald K. Ingram, Richard Weindruch, Rafael de Cabo, and Rozalyn M. Anderson. “Caloric Restriction Improves Health and Survival of Rhesus Monkeys.” Nature Communications 8, no. 1 (January 17, 2017): 14063. https://doi.org/10.1038/ncomms14063.
Abstract: Caloric restriction (CR) without malnutrition extends lifespan and delays the onset of age-related disorders in most species but its impact in nonhuman primates has been controversial. In the late 1980s two parallel studies were initiated to determine the effect of CR in rhesus monkeys. The University of Wisconsin study reported a significant positive impact of CR on survival, but the National Institute on Aging study detected no significant survival effect. Here we present a direct comparison of longitudinal data from both studies including survival, bodyweight, food intake, fasting glucose levels and age-related morbidity. We describe differences in study design that could contribute to differences in outcomes, and we report species specificity in the impact of CR in terms of optimal onset and diet. Taken together these data confirm that health benefits of CR are conserved in monkeys and suggest that CR mechanisms are likely translatable to human health.
For human studies, here's a recent one:
Redman, Leanne M., Steven R. Smith, Jeffrey H. Burton, Corby K. Martin, Dora Il’yasova, and Eric Ravussin. “Metabolic Slowing and Reduced Oxidative Damage with Sustained Caloric Restriction Support the Rate of Living and Oxidative Damage Theories of Aging.” Cell Metabolism 27, no. 4 (April 3, 2018): 805-815.e4. https://doi.org/10.1016/j.cmet.2018.02.019.
"Findings from this 2-year CR trial in healthy, non-obese humans provide new evidence of persistent metabolic slowing accompanied by reduced oxidative stress, which supports the rate of living and oxidative damage theories of mammalian aging."
So we have to make the best of other evidence, like animal studies (rats have increased lifespan on restricted calories), observational studies, and biomarkers.
Are you taking it?
The actionable stuff will be 3 dot points as with all books.
1-2 extended fasts per year.
I am wondering about another approach involving a bumping up of protein (0.75 g/lb for 2 days, 1.00 g/lb for 2 days, and 1.25 g/lb for 2 days) and a 42-hour dry fast wrapped around the 7th day. Melatonin (and calories missing on the 7th day) would be taken on the 6 feeding days. Last meal 3-4 hours before bed either way. The fast resensitizes to protein, same as happens when it's bumped up on 3rd days.
While many cry out against mTOR, it is responsible for synthesis of many relevant proteins: creatine, glycine, collagen, etc. The issue is more with mTOR being out of balance with AMPK. Melatonin and dry fasting helps restore the balance.
Ideally, one would increase IGF-1 as much as could be done naturally (ie, vitamins/minerals and eating frequency rather than excess protein or direct supplementation). DHEA, melatonin/progesterone, and hGH would then be adjusted to match the associated growth/pubertal year (eg, matching hormone levels of a 15 year old).
David A. Sinclair, Ph.D., A.O. is a Professor in the Department of Genetics and co-Director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School. He is best known for his work on understanding why we age and how to slow its effects. He obtained his Ph.D. in Molecular Genetics at the University of New South Wales, Sydney in 1995. He worked as a postdoctoral researcher at M.I.T. with Dr. Leonard Guarente where he co discovered a cause of aging for yeast as well as the role of Sir2 in epigenetic changes driven by genome instability. In 1999 he was recruited to Harvard Medical School where he has been teaching aging biology and translational medicine for aging for the past 16 years. His research has been primarily focused on the sirtuins, protein-modifying enzymes that respond to changing NAD+ levels and to caloric restriction (CR) with associated interests in chromatin, energy metabolism, mitochondria, learning and memory, neurodegeneration, and cancer. The Sinclair lab was the first one to identify a role for NAD+ biosynthesis in regulation of lifespan and first showed that sirtuins are involved in CR in mammals. They first identified small molecules that activate SIRT1 such as resveratrol and studied how they improve metabolic function using a combination of genetic, enzymological, biophysical and pharmacological approaches. They recently showed that natural and synthetic activators require SIRT1 to mediate the in vivo effects in muscle and identified a structured activation domain. They demonstrated that miscommunication between the mitochondrial and nuclear genomes is a cause of age-related physiological decline and that relocalization of chromatin factors in response to DNA breaks may be a cause of aging.
Dr. Sinclair is co-founder of several biotechnology companies (Sirtris, Ovascience, Genocea, Cohbar, MetroBiotech, ArcBio, Liberty Biosecurity) and is on the boards of several others. He is also co-founder and co-chief editor of the journal Aging. His work is featured in five books, two documentary movies, 60 Minutes, Morgan Freeman’s “Through the Wormhole” and other media. He is an inventor on 35 patents and has received more than 25 awards and honors including the CSL Prize, The Australian Commonwealth Prize, Thompson Prize, Helen Hay Whitney Postdoctoral Award, Charles Hood Fellowship, Leukemia Society Fellowship, Ludwig Scholarship, Harvard-Armenise Fellowship, American Association for Aging Research Fellowship, Nathan Shock Award from the National Institutes of Health, Ellison Medical Foundation Junior and Senior Scholar Awards, Merck Prize, Genzyme Outstanding Achievement in Biomedical Science Award, Bio-Innovator Award, David Murdock-Dole Lectureship, Fisher Honorary Lectureship, Les Lazarus Lectureship, Australian Medical Research Medal, The Frontiers in Aging and Regeneration Award, Top 100 Australian Innovators, and TIME magazine’s list of the “100 most influential people in the world”.
https://genetics.med.harvard.edu/sinclair/people/sinclair.ph...
West, Michael D, Hal Sternberg, Ivan Labat, Jeffrey Janus, Karen B Chapman, Nafees N Malik, Aubrey DNJ de Grey, and Dana Larocca. “Toward a Unified Theory of Aging and Regeneration.” Regenerative Medicine 14, no. 9 (August 28, 2019): 867–86. https://doi.org/10.2217/rme-2019-0062.
Shetty, Ashok K., Maheedhar Kodali, Raghavendra Upadhya, and Leelavathi N. Madhu. “Emerging Anti-Aging Strategies - Scientific Basis and Efficacy.” Aging and Disease 9, no. 6 (December 4, 2018): 1165–84. https://doi.org/10.14336/AD.2018.1026.
Brown-Borg, Holly M., and Rozalyn M. Anderson. “Metabolic Adventures in Aging Research.” Molecular and Cellular Endocrinology, Metabolism of Aging, 455 (November 5, 2017): 1–3. https://doi.org/10.1016/j.mce.2017.08.012.
Longo, Valter D, Adam Antebi, Andrzej Bartke, Nir Barzilai, Holly M Brown-Borg, Calogero Caruso, Tyler J Curiel, et al. “Interventions to Slow Aging in Humans: Are We Ready?” Aging Cell 14, no. 4 (August 2015): 497–510. https://doi.org/10.1111/acel.12338.
López-Otín, Carlos, Maria A. Blasco, Linda Partridge, Manuel Serrano, and Guido Kroemer. “The Hallmarks of Aging.” Cell 153, no. 6 (June 6, 2013): 1194–1217. https://doi.org/10.1016/j.cell.2013.05.039.
A couple resources for keeping track of recent developments:
* https://www.lifespan.io/road-maps/the-rejuvenation-roadmap/
For sure something is keeping people looking and acting younger.
It also doesn’t help that he wasn’t exactly in good shape.
It’s quite a bit about genetics and lifestyle look at Val Kilmer for example he aged quite terribly and he is only 2 years older than Tom Cruise but looks 2+ decades older.
Further to that his dedication to the art is second to none, whether it involves learning a new language or performing stunts and physical feats at an almost Goggins-like level of defying what's possible.
I see a sharp mind in a trained body, belonging to a person with an impeccable work ethic.
At this point his movies are what crazy stunts can I get the studio to pay for today.
My father who will be soon 70 is doing hiking in mountains pretty much all summer, while his mother when she was in her 80s took care about her house, garden and animals and only in the very end with tumor on brain experienced very fast decline.
I'd say, just stay active, don't sit at home all the time, if you want to stay in good physical condition and socialize to keep good cognitive functions.
Melatonin (sustained-release) is the big secret weapon against aging, especially when started younger (right after growth years). And eating the last meal 3-4 hours before bed or earlier. And meeting all RDAs with just a variety of whole quality foods (most don't meet all RDAs, especially with just food). 1:1:1 calcium:phosphorus:magnesium.
I know the calorie restriction work has been replicated in the lab with animal models, but of course a human study would face most likely insurmountable ethical challenges.
People who are now 75-80 had much better nutrition than generations before them. Life expectancy in Finland is projected to increase even more in the future.
Calorie restriction starts to make sense only after adulthood. Prenatal, natal and child nutrition and calorie availability is probably the most important thing extending lifespan.
Finland had a famine 1867-1868. After that expected lifetime started to increase. There was a dip in generations born around civil war and then again during the Winter War and WWII. After that life expectancy continued to increase.
Source: Expected lifetime of population by year of birth. https://www.stat.fi/org/tilastokeskus/elinajanodote.html
I think we have to separate the quality of the food (vitamins, fiber, protein, sodium, etc.) from the quantity that was available, and when. You can have the lack of food in certain periods in Finland in the last 75-80 years, e.g. due to WWII. At the same time it's possible to have better food quality in the same period, due to increased globalization, since Finland probably never had so much access to fruits and vegetables in winter as it does in the last 80 years.
https://www.pnas.org/content/106/41/17290
>Population health did not decline and indeed generally improved during the 4 years of the Great Depression, 1930–1933, with mortality decreasing for almost all ages, and life expectancy increasing by several years in males, females, whites, and nonwhites. For most age groups, mortality tended to peak during years of strong economic expansion (such as 1923, 1926, 1929, and 1936–1937). In contrast, the recessions of 1921, 1930–1933, and 1938 coincided with declines in mortality and gains in life expectancy.
Must have been awkward as a child.
https://www.discovermagazine.com/planet-earth/the-worst-mist...
Sounds like it would be a trade-off then, not a clear favorite, depending on what you're optimizing for. Especially when we can afford to focus on maintaining health at an individual level too.
So, it depends on what you mean by “youth”. If you include anything below the 20s or so, then the answer is a strong, emphatic no.
My grandfather is now over 90 years old, and his and my grandmothers diet has mainly been: 1) meats of different kind, sourced of course from grocery shops but also in a significant portion from nature (hunting) 2) fats, definitely of the saturated kind (animal + butter) 3) potatoes.
There were no salads, olive oils or anything deemed healthy by the modern standards on their plates. There were also no hamburgers, chips (or crisps if you're British), no coke (Coke arrived in Finland in the Olympic year 1952 - but it was deemed unhealthy VS orange soda, maybe by the benefit of the local soda company's marketing) and the main sugary treat was licorice candy and the occasional chocolate.
In summary, lower meal frequency would definitely be true, but also a diet with much more "close to source" ingredients.
(Yes, anecdata)
Also keep in mind that mortality increases exponentially with age.
Either way, it is important to know what is reported when doing comparisons.
Edit: of income I mean. Wealth is also maybe interesting
It better be. I expect the retirement age where I live to be over 70 by the time I retire (it is currently 68)
Finland has also come from a lower place than their neighbours so it's more pronounced. But childhood nutrition matters.
There were many more automobiles post WWII than in the era prior also.
Better nutrition and medicine have to be a big piece of it.
A lot of good that did me!