Tup requires FUSE, so is a deal breaking dependency for many corporate setups due to security.

If you’re into Tup, you might also like https://github.com/droundy/fac

Fun fact: ninja was inspired by Tup, but is a bit more geared toward pragmatic usages.

I used to use tup for small projects but then I switched to CMake/ninja.

I can't say anything against tup other than it is not widely used. In terms of performance, I did not notice any difference between tup and ninja -- but these were small projects.