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If the modifications go far enough (e.g. something like completely suppressing all human emotions) I'm pretty sure it's fair to say that we'll be gone. At least I don't see any reason why we should view these potential future 'humans' as any thing more related to us than say a potential 'species' of robots.

Humanity will end the same way the neanderthals ended. Extermination by the "superior" life form.

Depending on the ancestor we may have already qualified centuries if not millenia ago - but that has more to do with them than us. If they call those who do not worship their long forgotten gods not human then we technically already lost. Let alone other specific aspects like not considering pygmy peoples human.

The point being hypothetical bigotries of the long dead is an unmeasurable metric (oxymoronic) and pretty useless.