Well, LaTeX is great for mathematical symbols. I have not seen a typesetting in the web space that can compare itself to LaTeX. This is why scientists from the exact sciences use it.
Static site generators like Sphinx, Hugo, and Jekyll have support for MathJax which allows for inline equations in Markdown/RsT docs. See a Sphinx example here [1].
[1]: https://www.pflotran.org/documentation/theory_guide/mode_th....