This can be seen quite a bit on Twitter, both in usernames and the tweets themselves. Personally, since I think human behaviour cannot be completely fixed but can be nudged in the correct direction, I'd like to see services implement something like alt text for text, especially usernames. This way people can use different characters to be as creative as they want, but provide an accessible version for screen readers. Something like this example:

    <span aria-label="like this example"><span aria-hidden="true">𝕝𝕚𝕜𝕖 𝕥𝕙𝕚𝕤 𝕖𝕩𝕒𝕞𝕡𝕝𝕖</span></span>

The alternative would be restricting the use of these characters, but this would kill many valid use cases and you can't just forbid non-latin characters on an international service.

I've written a post[1] about this and thought I'd implement it in one of my services as an example. I haven't seen any example of it live yet.

[1] https://blog.nytsoi.net/2019/12/12/alt-text-for-text