Repressed humour from the programmer son of a pathologist.
My favorite dad quip was 'Biology itself is proof against an intelligent designer.'
My favorite dad quip was 'Biology itself is proof against an intelligent designer.'
Evolution isn't going to nicely separate functionality into clean, single-purpose biochemical pathways.
It's going to overload something that it already has to support a new feature, leading to a rat's nest of intertwined effects.
The hard part in drug development isn't affecting your target: that's pretty easy to guarantee with modern tools. It's finding out that that target also governs 10 other, completely unrelated bodily functions.
Some companies in the valley just call that Wednesday.=)