This cultural divide has deep roots in the power struggle that was created when the people who settled the Appalachian's figured out that converting fields of corn into distilled bottles of whisky was far more profitable since it could travel infinitely farther without spoilage along the trade routes.
They were "dirt poor" prior to this because they could generate fresh produce that had a limited scope and value on the market.
That's when the war on stills began and there was a very thorough campaign of misinformation about how "dumb hillbillies" were going to blow themselves up/make everyone blind trying to operate a simple still.
It was really about the potential shift in economic power if that region was able to leverage vast lands for growing and creating highly profitable alcohol that could be sold across the country.
That campaign/lobby was so effective that it still resonates to this day.