Yeah, I think it has to be something that can be considered an enemy, not something that'll do us harm because that's how things are but has no mind of its own. A virus, diabetes or global warming aren't going to work as good (my intuition is that men need it to be an actual enemy more than women, but I have no idea).
I do believe that e.g. Americans would be much more compliant in corona-mitigation-things like wearing masks if the narrative was "China has sent us a Virus to destroy us". But that would obviously also create serious issues because they'd demand revenge.
A secretive alien enemy has sent us a Virus, and they're also trying to cook us alive by heating up our planet. Are you going to just let them do it to us, or will you stand up and fight for our way of life, against the intergalactic threat? Now that's a They that can provide a We for Team Humanity, Leaders Of The Free Universe.