As to your claim about antidepressants, psychiatry and psychopharmacology is abound in RCTs, many on treating depression with antidepressants. You are perhaps mistaking a common clinical approach (outside of clinical studies) for finding the best medical management for single patient with how clinical evidence is procured in the first place. There are more Cochrane reviews under "mental health" at 679 than there are under "orthopedics" at 478.
Also, when RCTs are proposed, no matter if they placebo controlled or not, they are reviewed by IRBs and ethics committees.