I use spotlight for all kinds of math (12 / 4) * (44 + 35) etc
Command + c will copy the highlighted spotlight result.
Expose (show all windows) and drag and drop files to that window (i grab the file, while dragging show all windows by either a keybord key or hot corner and drop it to the new window)
Hold down command to move around background windows without giving it focus.
Ctrl + (arrows or numbers) to go to certain spaces.
While in spaces expose, hold down ctrl to move all of the windows of a certain application to another space.
Hold down a window's titlebar while switching spaces to move that window to the new space.
Drag folders that you frequent into the left side of finder. I have /private/etc in mine
Hold down command while clicking or pressing enter on a spotlight result will open its containing folder.
How did I forget about keyboard modifiers by holding down the alt key.
Drag a file/folder to terminal to get the path to that file printed in terminal. so I often type "cd " and then drag folder to get there
While switching apps via command+tab you can let tab go and either hide the application by pressing h or quit it by pressing q (I wish that you could minimize it by pressing m). You can also cycle backwards by pressing tilde (this only works if youre already command+tabbing) or shift+tab
* Gone from snow leopard, but i miss it* there used to be a keyboard shortcut (command, option, ctrl space) that opened a list of your last accessed files (i mistakenly found a bunch of porn website cookies on an intern's laptop once). This used to be useful to see which files you needed to upload /ftp.