Out of curiosity, what laptop models + distros have you tried to set up?
On Acer Nitro 5 with Nvidia GTX-1060Ti and i5, stock Ubuntu 20.04 loaded no problems, and even DisplayLink driver for dual monitor, one through regular HDMI + other through USB -> HDMI adapter worked (though I couldn't get it to rotate display vertically).
The bugs I did have were with it constantly re-disovering network printers that I had to disable, and changing the default wifi power-saving settings because something was funky with it.
On Asus TUF A15 with Nvidia RTX-2060/AMD Renoir + AMD Ryzen 7 4800h absolutely no distro worked out-of-the-box and I needed mainline kernel + latest Nvidia drivers. But after fixing that myself Pop_OS picks up everything perfectly and no problems.
Both of them have CUDA working IIRC (at least running "nvidia-smi" says it does).